Mechanism by which Human Papillomavirus 16 Infection Interferes with Progression and Immune Evasion of Cervical Cancer by Acting on Th9 Cytokines

High-risk human papillomavirus types are associated with most of cervical cancer cases. To explore the mechanism by which 16 infections interferes progression and immune evasion acting on T helper 9 cells cytokines. Cervical were obtained from China Center for Type Culture Collection. Cells cultured in Roswell Park Memorial Institute Medium-1640. Through wound healing test transwell analysis, effect interleukin-9 movement, migration invasion was evaluated. The expression epithelial-mesenchymal transition markers programmed death-ligand 1 cell death protein messenger ribonucleic acid detected. Human receptor had higher tumor tissue than normal group. proliferation inhibited transfection group compared Interleukin-9 reduced N-cadherin vimentin expression, increased E-cadherin expression. inhibition decreased while These cytokines can limit proliferation, invasion. They induce up-regulation inhibit thereby expressing antigens.